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Compounded Semaglutide Now Available

If you want help on your weight management journey, Semaglutide can help. See if Semaglutide is right for you.

Compounded Semaglutide Now Available

If you want help on your weight management journey, Semaglutide can help. See if Semaglutide is right for you.

What is Semaglutide?

Semaglutide is a glucagon-like peptide (GLP-1) analog approved in 2017 as a treatment method for improving glycemic control in patients with Type 2 diabetes. Semaglutide shows great promise for patients who are having difficulty losing weight.

Studies have demonstrated that Semaglutide reduced appetite, improved control of eating, and reduced food cravings in addition to improved glycemic control. The greatest weight loss benefits were observed when Semaglutide is used in combination with lifestyle changes, such as improved diet and
consistent exercise.

Reported Benefits:

Semaglutide Average Weight Loss

How does it work?

It aids in weight loss by signaling the brain that your stomach is full, while also slowing down gastric emptying. This allows patients to experience less hunger and feel satisfied with fewer calories.

What are the most common side effect I can expect?

The most frequently reported side effects of this medication are related to the gastrointestinal (GI) system, including abdominal pain, constipation, heartburn, indigestion, diarrhea, nausea, and vomiting. These side effects may be more noticeable when starting the medication (especially if using a higher dose than prescribed) and during the dose escalation period. If you are new to taking semaglutide, your healthcare provider will provide specific instructions for titration. This involves starting with a small dose and gradually increasing it to minimize the occurrence of the above-mentioned side effects-

How Should I Store This Medicine?

Keep product refrigerated. Keep all medications out of the reach of children and pets.

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Frequently Asked Questions

Why don’t you ship out semaglutide compounds on Fridays or the weekend?
Injectable medications such as semaglutide require temperature control, and we cannot take the risk of packages being exposed to high temperatures in trucks or warehouses over the weekend. We use special packaging that include ice packs for our shipments. Please note, the ice packs and medication might be warm when you receive it, but the procedure we use to ship will help prevent the semaglutide from losing its effectiveness. Please store the medication in the refrigerator as soon as possible.
How is it legal to compound semaglutide?
FDA approved brand drugs with semaglutide are currently in drug shortage. In situations like this, pharmacies are legally able to compound them. To the best of our knowledge, as long as semaglutide sodium or semaglutide acetate are not utilized, this practice is common and legal.
What causes delays in shipping/receiving the medicine?
The pharmacy needs to speak with the patient to verify allergies, shipping information and credit card information (when applicable) before we can process and ship the medication. Shipments are sent Monday through Thursday, depending on the timing of when the prescription was received as well as patient responsiveness.
What else is provided with the injectable medication?
Syringes and alcohol pads/swabs for sterilization are included.
Can patients use auto-injectors available from retail outlets like Amazon?
No, our compounded semaglutide will come in a vial and can’t be put into auto-injectors.
What other over-the-counter supplements or medications do you suggest taking alongside semaglutide?
Recommended supplements to take alongside semaglutide include:
  • Probiomax Lean and Leptin Manager are highly recommended to help boost weight loss as well as minimize GI side effects.
  • If Probiomax Lean is not preferred, taking a prebiotic/probiotic combination is recommended.
  • For constipation relief, options include stool softeners like Colace, magnesium products such as Natural Calm or Mag07, and herbal teas.
  • Heartburn can be managed with PPIs like Prilosec and Nexium.
  • Additionally, it is advisable to take a multivitamin and a B complex vitamin.
Is there a web portal for ordering/paying?
Unfortunately, we do not have the capability to provide this service. However, we do offer the option to securely store a credit card on file for clinics and patients. The card will be charged for each prescription dispensed. For established clinics, there is the possibility to set up an Accounts Receivable account with our pharmacy, allowing them to bill for prescriptions on a monthly basis. Monthly statements will be mailed out, and receipts will be included with each shipment.
Why does the pharmacy contact the patient even if the medication is billed and shipped to the clinic?
In accordance with regulations set by the Texas State Board of Pharmacy, we are required to contact the patient directly to verify any allergies they may have. We also inform the patient that the medication will be billed and shipped to the clinic, and any payment owed (if applicable) will be managed by the clinic.
Can we request rush orders?
Unfortunately, rush orders for compounding injectable medications are not feasible due to their specific nature. Our pharmacy receives a high volume of orders daily, and the process of accurately preparing, labeling, and shipping medications requires sufficient time. We want to assure you that our dedicated pharmacy teams strive to work as efficiently as possible to fulfill all orders promptly.
For the sublingual Semaglutide compound, what flavors does it come in?
This compound comes in raspberry or chocolate flavors.
Why don’t you ship out semaglutide compounds on Fridays or the weekend?
Injectable medications such as semaglutide require temperature control, and we cannot take the risk of packages being exposed to high temperatures in trucks or warehouses over the weekend. We use special packaging that include ice packs for our shipments. Please note, the ice packs and medication might be warm when you receive it, but the procedure we use to ship will help prevent the semaglutide from losing its effectiveness. Please store the medication in the refrigerator as soon as possible.
Why should I rotate the area I am injecting the Semaglutide into?
Repetitive injections in the same spot can lead to the development of lumps under the skin, which can irritate and cause discomfort. Overusing one spot can also make the medication less effective. To avoid this, rotate the injection site with each dose. When shifting injection sites, move in a circular motion around each area to avoid repeatedly injecting too close to one another. A patient can keep track of their injection spot by marking it with a pen before inserting the needle.
Is it typical to experience a decrease in appetite when starting the medication, and what suggestions can be offered to ensure adequate protein intake?
Absolutely! To boost your protein intake, consider having protein shakes in the morning, carrying beef sticks and protein bars for snacks, and including a few servings of nuts in your daily diet.
What can I do to minimize symptoms of heartburn, indigestion, and acid reflux?
Daily use of PPI’s, such as Prilosec or Nexium (available over the counter), can help reduce heartburn and acid reflux symptoms. Additionally, drinking more water, eating smaller meals, and taking Pepcid before bed may also help alleviate these symptoms.
When will I start to notice a decrease in my hunger pangs after I start taking the medicine?
While some people may see a decrease in appetite in the first few days or weeks of starting the medication, it is not common. To decrease the likelihood of side effects, we start you on a low dose that gradually increases every few weeks. The majority of people will see the greatest reduction in hunger pangs after reaching their Maintenance Dose, which usually occurs after the second month of treatment.
I am experiencing constipation and bloating while taking the starting dose. Is this temporary, and are there any tips to reduce discomfort?
Gas-X (Simethicone) is a popular OTC option for bloating. Additionally, taking a daily prebiotic/probiotic can help prevent the symptoms from occurring. For constipation, stool softeners such as Colace (docusate) can be helpful, as well as Magnesium products (Natural Calm and Mag07 are highly recommended). Drinking herbal teas like Smooth Move may also help with constipation caused by medication.
Is it common to have low energy levels after taking the medication? What should I do if I experience this?
If you’re feeling low on energy, try drinking a glass of water when you wake up and doing some exercise or movement for 10-15 minutes. Yoga, walking or your favorite exercise can help to boost your metabolism. Additionally, taking a daily multivitamin and B-complex supplement has been known to help with energy levels.
Are there any recommended supplements to take while starting the medicine?
Absolutely! Incorporating a prebiotic with a probiotic, like Zenwise, is highly recommended to alleviate indigestion and heartburn. Additionally, it’s a great idea to consider taking a multivitamin with iron and a B complex vitamin.
Since my last dose increased, I’ve been experiencing more heartburn and indigestion. How can I modify my diet to help stop this?
Avoid eating greasy, fried and fatty foods. Avoid sugar/candy, chips, and snacks. Eat lean proteins and veggies/fruits at the beginning of your meal then a small amount of carbs at the end.
I’ve come across wellness centers and med spas that offer compounded peptides while researching Semaglutide. Are these the same as what I would get from a compounding pharmacy?
No, they are not the same. Legitimate compounding pharmacies, such as Smithville Pharmacy, strictly adhere to FDA regulations and require a valid prescription from a doctor. They compound medications using FDA-approved formulas and medications. On the other hand, wellness centers typically utilize research peptides that are not intended for human consumption or use. These peptides lack FDA approval and have no documented studies on their safety and effectiveness.
What is the recommended daily protein intake while taking the medication?
The ideal amount of protein you need daily may vary depending on your individual needs. It’s best to consult with your doctor to determine your specific protein goal. However, starting with more than 100g/day of protein is a good general guideline. You can increase your protein intake by incorporating protein shakes into your diet, prioritizing protein-rich foods like lean meats (chicken, turkey, fish), eggs, beans, and vegetables.
What is the duration of treatment with Semaglutide, and what occurs upon discontinuation?
The duration of Semaglutide treatment varies depending on individual circumstances, and your healthcare provider will determine the appropriate length for your specific needs. When it comes to discontinuing Semaglutide, it is crucial to follow your doctor’s guidance. Upon discontinuation, your healthcare provider will guide you through an appropriate plan, which may involve transitioning to an alternative treatment option or adjusting your medication regimen. It is important to have open communication with your healthcare provider to ensure a smooth transition and ongoing management of your health.
Is it a cause for concern if my semaglutide reaches room temperature or becomes warm during shipment or while traveling? Will the medication still be effective?
As long as the bottle doesn’t spend a significant amount of time in extreme heat, it should remain effective. Please continue to store it in the refrigerator as much as possible.
I’ve experienced appetite suppression, but not significant weight loss, in the first two months on semaglutide.I’ve noticed that some people achieve rapid weight loss, but I feel like I’m barely making progress and I’m concerned that the medication may not work for me. Has anyone else had a similar experience?
It’s important to remember that everyone’s response to medication can vary. While some individuals may experience rapid weight loss with semaglutide,it doesn’t necessarily mean that the same will apply to everyone. It’s crucial to stick with the treatment and give it more time. Keep in mind that semaglutide is typically titrated to reach the most optimal dose for appetite suppression, and the corresponding benefits may become more evident over time. You may not have reached the dose that works best for you yet. It’s recommended to continue following your healthcare provider’s guidance and monitor your progress, and to reach out to them with any concerns.
How should I address Sulphur Burps?
To alleviate Sulphur Burps, it is recommended to steer clear of fried and greasy foods. Consider replacing your breakfast with a protein shake in the morning, and ensure you stay well-hydrated by drinking plenty of water.
How long does it take to lose weight on Semaglutide?
With Semaglutide, you will slowly work your way up to the target dose, at which time you will see the most amount of weight loss. This was the case in the clinical trials, where participants had their dose adjusted until they reached 2.4 mg once weekly. Most participants were able to reach the full dose and also lost more weight as their dose was increased. They then saw additional weight loss over the remaining 48 weeks at the full dose. It is important to keep in mind that patients will see the best results when medication is taken in combination with a healthy diet and exercise.
What is the pricing for clinics that want to do injections for patients at the clinic?
The pricing does not change.
What type of provider can write a prescription for Semaglutide?
Any prescriber authorized to write prescriptions can also write for Semaglutide. Nurse Practitioners (NP’s) and Physician Assistants (PA’s) will still need a supervising MD.
How do doctor offices and clinics who want the medications shipped directly to them (and not the patient) pay for it?
We do not have a “portal” for offices to pay for semaglutide. We are offering to keep a credit card on file for providers/clinics, and we can charge the card daily or monthly with an AR account for the clinic. Statements are mailed out the first of every month. We will also include receipts in the shipments.
Please Note: Even though the script may be billed & shipped to their office, we still have to reach out to the patient to verify drug allergies per TSBP law. When we do this we’llll let the patient know that the medication is being billed and shipped to the office, who will be contacting them when they receive it. We are not giving out any pricing info in case the office is charging something different.
What if the clinic doesn’t have fax capabilities?
Email prescriptions to info@smithvillepharmacy.com
Why don’t you ship semaglutide compounds on Fridays or the weekend?
Injectable medications such as semaglutide require temperature control, and we cannot take the risk of packages being exposed to high temperatures in trucks or warehouses over the weekend. Many doctors offices and clinics are closed on the weekend. Also, we utilize a reliable next-day courier service to ship to as many locations as possible please, but unfortunately our courier does not offer weekend delivery and there are certain areas they do not service. We ship with UPS to those areas, and they too don’t deliver on the weekend.
To ensure the medication’s integrity, we use special packaging that includes coolers. It is crucial for clinic staff and patients to be aware that immediate refrigeration of the medication is of utmost importance.

Learn more from Dr. James Notte, our Pharmacist in Charge

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